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Taylor Ealand: [00:00:00] Hi, my name is Taylor Ealand. I'm one of the co-hosts of contracts, normally a political podcast, but today we're taking a trip down COVID lane scientific lane backed by lots of evidence. There will be sites and a document provided in the description. As with every episode of contracts, everything anyone says me or the guests can and will be held against us in the court of public opinion.
[00:00:31] Although due to the nature of the. Doesn't really fit that quote because longtime listeners understand. So here's where Ram I did an episode with URI Dagon, um, check it out if you haven't and we talk about ivermectin and we kind of go, um, against some of the anti-vax rhetoric coming from people like Brett Weinstein, certain elements of the conservative, right.
[00:00:49] That conversation is kind of, it stands on its own. This is supplementing that conversation. But if you're hesitant about the vaccine, this is probably the more important one. The last one has to deal more with ivermectin. Uh, it talks, there are some generalities about the vaccine, which I think are important to understand.
[00:01:04] But again, if you're worried about, should you get the vaccine? This episode has tons of information. So here's how it's going to go. I put the more interesting part in the beginning, and what I did is I got a PhD in microbiology is one way to put it, to talk about the mechanisms of COVID-19. And the mechanisms of the vaccine.
[00:01:26] This is a political podcast. There was a, there are a couple parts where the guest goes into masks. You will see me not really engage. I'm not here to talk about masks or policies. Uh, today there is a very simple goal. I am trying to tackle this issue by separating the conversations that are intermingled right now.
[00:01:46] I see lots of people who are hesitant being hesitant because of government reasons, because of policy reasons. For this episode, please separate the two. Today. I am tackling the science questions. I am not tackling the policy questions. I have brief commentary at the end of the video about what I think policy wise kind of, sort of, so keep that in mind.
[00:02:11] So don't put your biases about Trump or Biden. Hello, seam Connell, whatever vaccine person you do, or don't like put your biases about them away from this episode lease, please. If you do, this will be a much more beneficial episode for you. It's going to start with an interview with Dr. Story, a professor at Gordon college, you can say COVID is in his wheelhouse.
[00:02:38] He spent lots of time going through the literature. This is something he's very interested about. He's very vocal about, uh, links to some of his stuff. If I find that will be below, please again, separate science and policy. The second part, which might actually be longer than the first is me going through.
[00:02:55] There is a document I'm holding on my iPad because it's when I'm reading, when I'm going through it, going through the notes that I had made prior to the interview, complete with citations to scientific articles, not CNN articles. Not Fox news articles, not AP articles, actual scientific literature, respected scientific literature.
[00:03:16] I'm not talking to the Carvello study with five people in it. I'm talking review articles that pull from dozens of other articles that can create this very complicated spider web of evidence supporting Mike attentions much more rigorous than the anti-vaxxers are cleaning with their five or four studies of the key pieces.
[00:03:36] To promote ivermectin, for example, much more rigorous and put them there so that you can check my work. You can read along, you can read it yourself. See if I read something wrong. That way you can tell me I'm wrong with my own sources that I provided for you to read. You can go down all the rabbit holes of whatever particular, um, the discussion interests you.
[00:03:57] If you want to learn more about the damage that COVID can do to your brain or do your laundry, you want to learn more about how the vaccine works. You can click on the articles that I provide and then click on the sites that those article provide to continue down the rabbit hole. If you're so pleased, I did this to make it abundantly clear that I do know what I'm talking about.
[00:04:15] I brought receipts and you can trust what you're hearing in this episode. So again, we're going to listen to Dr. Story of Gordon college, and then we're going to go over a lot of the same information, but some of it more in depth. Um, some of it to add my commentary because I try not to commentate while my guests are speaking too much on the show.
[00:04:35] At the end. This is a long episode, especially for a contract's episode. I think it's worth it. Thank you for watching. Enjoy the show. I am with doctors story of Gordon college. He's a professor of immunology and biochemistry there. He's been teaching there for almost 20 years safe to say again, you know, the ropes and your research has related to viruses and the immune system, your postdoc involved looking at other viruses, not particularly COVID, but things like herpes, which then allows you to kind of take those concepts and extrapolate out intelligently.
[00:05:10] One thing that you were talking about prior to the show that I have written down the notes that I want to open up with. So the listener understands, you mentioned how viruses often manipulate our immune systems and. Actually counterintuitively, but getting infected by a virus could be, you won't get as much immunity as you would if you got a good vaccine, which I didn't know, I kind of figured that they operated similarly to my understanding of bacteria, which is natural immunity, vaccine immunity.
[00:05:38] It's very similar. So already you're kind of busting misconceptions that I'm running into with virus. Cause one of the most common things I see people say is, you know, why would I get the vaccine? I'll just get it naturally. And on the same immunity. And it might actually be the case where that's not as helpful as people think it is.
[00:05:55] Craig Story: [00:05:55] Yeah, that's right. Um, um, many viruses in do this. They, they manipulate the immune system to like not be noticed so that they can replicate themselves. That's that's a good virus, a virus that doesn't really make us very sick. Yes. SARS go Coby too. Um, COVID as we call it does make us sick, but, um, it it's likely to happen.
[00:06:17] Genes that manipulate our immune system so that we do not get as high a level of immunity. Um, that's a trend for many viruses. So, so vaccines on the other hand are specifically designed to provoke the immunity, uh, to make us provoke a strong antibody response and a strong cellular response to the virus.
[00:06:37] So unlike the actual infection, the vaccine won't make us sick. So there is definitely another advantage to vaccine over the natural way of becoming immune. And
[00:06:49] Taylor Ealand: [00:06:49] then just blaze through the basics here. I also see a lot of people who will justify not getting vaccinated because of a low death rate. And, you know, on first pass, this seems to make sense because what a lot of the media was sort of portraying early on was primarily about death.
[00:07:06] It wasn't really about other issues that could start coming out of COVID-19. COVID is much more than just death though. Uh, the paper that I found kind of outlined four different stages, and many, most people get stuck in stage one, which isn't that big of a deal. Once you start getting into stage two, things can get really bad really quickly.
[00:07:25] So there's more so you could get blood clots, you could get long-lasting pulmonary damage, which is damaged to the respiratory system. And I mean, the paper that I saw was that stage three and four, you're starting to getting into neurological symptoms and degregation of the blood brain barrier, which to me is terrifying.
[00:07:39] I can't imagine. Um, at my age being affected by that,
[00:07:43] Craig Story: [00:07:43] well, a lot of people loss of sense of smell. It was one of the early surprising, uh, effects of this virus. And I believe what is happening there. And the kind of the, the sense of smell is neurological. Of course. And you have the olfactory. Uh, neurons that have nerve endings.
[00:08:00] They have endings in the, the sensory cells have tips in the nose and the nasal epithelium, and then they lead back into the brain. And I believe I heard, uh, a researcher studying this, saying that some of the supporting cells that support what these cells are, Don are being targeted by the virus. And so it could be that some of the neurological supporting cells are being killed and making this the nerve type cells or the sensory cells not function properly.
[00:08:28] And so, in a way that's a sign of a form of a sensory damage or neurological damage. I mean, you could even use the word brain damage. So, I mean, I think people started to think of, wow, this fires causes brain damage and look at the look at the effects of, um, brain fog. Right? That's the other very common.
[00:08:47] In fact, I mean, that's, that's, that's a form of brain damage, not to say that the brain can't recover some or maybe even all function, but people are suffering for extended months with these symptoms. And that is a very serious thing to think about. And so, right, the virus causes this and maybe up to a third of the people infected, I've heard, um, a large number of people and the vaccine does it.
[00:09:10] So, so like, which is better it's it seems to me so straightforward. And so maybe we should talk more about some of the concerns you've heard that people have about the vaccine. There's a lot of mystery about how does it work? Oh, it's new. We're not sure if it's going to be safe. Long-term things like that.
[00:09:28] And as a biologist, I think I, I feel very comfortable. Well, knowing what I know about biology, that this is a highly unlikely to have very long-term effects, mainly because it's gone after a short window of time. And what remains is your immune cells ability to recognize the current coronavirus?
[00:09:46] Taylor Ealand: [00:09:46] Yeah. I, I will get to the vaccine, but a lot of the misconceptions, I want to start with, start with the virus because a lot of people think that they're because they're my age, they're 24 years old.
[00:09:55] Right. They're basically immune to it and sure, like the brain can heal, but the brain doesn't heal like skin does. So even if it does feel it's going to take much longer than an injury and other parts of the body, the same can be said in the lungs. I mean, it's not going to be as bad as the brain, but also lung tissue as much.
[00:10:12] It's very delicate and can also scar and cause issues that people just don't look think about. Which to me, I think is a great starting point because you can't walk around thinking that this is just another cold. It's not. And I just find it odd that people prefer the natural infection, um, because they, they have this.
[00:10:31] Very distorted. And it's a distance thing. It's not an intelligence thing. It's a very distorted view of biology from when they were in high school, which they may have gotten a, you know, even a decent grade in. Um, but since they're so far removed from it, they don't understand that just because natural immunity is a effective means for many diseases.
[00:10:49] Doesn't mean it's the preferred means. And then, and then they also have forgotten how things like MRMA works. I've I mean, we've all seen the people talking about how it's gene therapy, even though that's not how gene therapy
[00:11:01] Craig Story: [00:11:01] works, but yeah, like, well, think back in history, uh, to smallpox was a scourge of humanity and everybody was pretty much many people.
[00:11:10] A majority of people will be exposed to it sometime in their lives. And so most people had some sparks scars on their face from this horrible disease and it killed a large fraction of the people that got it. And the earliest form of vaccination was not surprisingly, uh, smallpox related. And before they figured out you could use a related species and it re related strain, if you will, the bovine strain to protect against the human strain, they would actually take and purposely give a small infection on the arm of the smallpox to a person.
[00:11:43] And it would kill the like maybe 1% or maybe looking around in that, or the order of magnitude the people. But if you got the smallpox, you would have an even worse situation. So back then there were even willing to suffer a milder infection of your, of your tissue of your arm. Say then get the actual disease because yeah.
[00:12:04] Even in the case of smallpox, uh, the disease was known to be so much worse than the actual, um, variolation or this kind of procedure that they did. Uh, and then of course, Jenner came up with the, the cow pox vaccine and the whole milkmaid story, and milkmaids were immune because they got little infections of the cow pus Jules on their hands.
[00:12:25] And, and, uh, and then, you know, there was always an anti-vaccine group then, uh, where they're very suspicious. Like, what is this gonna do to me, et cetera. So I think the way to fight that kind of worry and concern is by providing, providing more knowledge about not only the biology of like you're saying, like the biology of the viruses, what the viruses do, but also the biology of how the vaccines work.
[00:12:48] So, so we do know a whole lot about that. So I'm here to help explain.
[00:12:54] Taylor Ealand: [00:12:54] Right. So starting with the vaccine, a lot of people, and this kind of astounding to me, which I understand is my bias with my previous biology education. But a lot of people didn't understand that MRN is a naturally occurring substance in the body.
[00:13:08] So for the hesitant who like MRNs sounds scary, it's a completely normal product. We use it all the time. The analogy I use is like, you have to, you have to breathe, right. And breathing requires protein interactions. And in a really like long, boring way that you don't really care about in order to create those proteins and is involved in the process.
[00:13:28] And your body makes it naturally.
[00:13:30] Craig Story: [00:13:30] Yeah. If everyone knows, we have a lot of proteins in our body, a hemoglobin hair, keratin is our hair and our skin. Um, you know, this is act in my muscles and made a myosin and actin, like all of these are proteins. And so most of the stuff of our body is, is proteins. And so.
[00:13:48] Like where does the protein come from? Well, it's, it's created by linking together these individual monomers sub units. This is like a boring biology lecture, by the way, right here, this part. So you can skip ahead a couple of minutes if you don't want to learn it, but basically it's straight your cellular machinery strings together, these monomers into long chains, which then fold and precise ways and that's, uh, that's proteins.
[00:14:09] And so how do you, the cells know what order to put these monomers of proteins together? And they read it off of a, a tape, like a, like a message that's telling the cell make this, and that message is messenger RNA, M RNA. So, yes, it's an incredibly important molecule of a cell. It's one of the main kinds of nucleic acids of the cell.
[00:14:35] And it floats around in the cytoplasm instructing the cellular machinery to make proteins. This is one of the things it does to make proteins in a certain sequence. And this RNA that's being introduced, happens to encode the message to make the foreign protein, the spike protein. So the whole goal of which is for your body to make.
[00:14:57] A foreign protein, which will then lead your immune system to recognize it as foreign Intermountain immune responses against that foreign protein. And so there's no infection mechanism theoretically possible. There's nothing infective being put in. Nothing that can replicate in your body and messenger RNA.
[00:15:16] Once it's made in the cell actually only lasts a short time on the order of minutes to hours usually, and then it's gone and then your cell has this protein, which itself can have a longer half-life. It just needs to stick around long enough to trigger the immune response, which could be in the order of hours, days at the most, most likely not, not a terribly long time.
[00:15:37] It's a very temporary instruction. Molecule messenger RNA. Yes. In a normal part of the cell, as you said, Taylor, thank
[00:15:45] Taylor Ealand: [00:15:45] you. And Mr. And EY, isn't going in and messing with DNA. MRN is separate. It's put in the cytoplasm, but operates in the cytoplasm and DNA. Doesn't go into the cytoplasm. It hangs out in the new.
[00:15:57] You don't have to worry about any concerns about, you know, your DNA being
[00:16:01] changed.
[00:16:03] Craig Story: [00:16:03] Gene therapy. It's a, it is a temporary message. That's quite, um, short-lived in the cell. And, uh, and yeah, and so believe it or not, people were trying for many years to develop DNA vaccines, right. Where they would inject a small circle of DNA into your muscle.
[00:16:22] And it would then do the same thing. It would actually be, they would have to be converted from DNA into RNA, but then that leaves the open, the possibility since you're injecting in some DNA that maybe just possibly in very rare cases, that DNA could insert itself into the genomic DNA. Um, this would be maybe a few thousand nucleotides of DNA base pairs of DNA.
[00:16:45] In a 3 billion base pairs of genomic DNA. So very small amounts. So the chance of it doing damage would be very minimal and perhaps even worth doing. But we didn't ever think that the messenger RNA approach, which takes a shortcut, avoids the DNA, it just goes directly to the product you would want the DNA to make.
[00:17:04] We never thought as a, as people in the field never, um, expected that you could actually successfully introduce just the message there, RNA and get a good immune response. People most likely assumed that it would just not last long enough, it'd be gone before it could do its job. But lo and behold, they tried it out and it did actually.
[00:17:26] Right. And so this is the safety net because the studies that were done, uh, and no, uh, the shortcut is the manufacturing is very easy for this making messenger on. We can do that. This is not a hard thing to make. So the research, so the research and all that in terms of making it has been done over decades in terms of how to make messenger RNA and understand its function, then, uh, so you have this vaccine, the, the trickiest part of the whole thing is to get it in a form that it can be delivered into cells, which has, is the lipid, the lipid aspect, because, uh, you need to get it into some cells.
[00:18:01] So we combine the Mr. RNA with a lipid, which is basically a little tiny, teeny, tiny wobble of almost like a fatty oily molecule. And that when it fuse, when it hits a cell surface, it'll actually fuse and allow that miss variety to get into the cells. And then those liquids also are. Found in the body and they don't, you know, they don't do anything to your DNA.
[00:18:24] They're just there. And then they get degraded and broken down after relatively short time. So yeah. So all of this stuff is there in the vaccine to just deliver that message messenger, RNA, that message to make the spike protein, which is the foreign protein on none of the components seem to be anything are, are anything that will have long-term effects on your DNA.
[00:18:48] Or your biology in general, other than the immune system response that you want. So you
[00:18:53] Taylor Ealand: [00:18:53] flew through that and you, you knew the question that I was going to bring up next, but I do want to highlight it just so it's clear with what I was wanting to pull out there is been, you mentioned that we've known it for deck.
[00:19:05] We've known about the MRN, a concept for decades, and that there's been research going on and people often will point that out and they'll say, well, how come now? It works. And then you, you brought up the lipids. But that the traditional research that I found was that they were trying to use, I'm going to over.
[00:19:23] Big lipids to encapsulate the Mr. And a and provide the vaccine that way. And now we're using tiny limits and I'm not entirely sure on the reasoning, but it's not that the MRA was the problem is that when you put the RNA in the body, the body is a very hostile environment. And I think most people intuitively know this.
[00:19:44] So then we ran into this issue where we have to keep an alive, because it will degrade very quickly, as you said, minutes to hours, and we needed to provide a little capsule for it to go to where it's going to go. And the viruses have already figured this out. They use a protein shell. Um, everybody knows the picture of the Corona virus, where it's like this little circle with a bunch of dots on it.
[00:20:05] And the circle serves to protect the viral RNA, uh, while it's being delivered to the cells that it's going to affect, because if it were just floating. The hostile body would take it out. So that's, that's the new development. It's not the MRN. Is this rushed out therapeutic that we don't know anything about is that we didn't know how to deliver it effectively and safely to the cells that need
[00:20:29] Craig Story: [00:20:29] it.
[00:20:29] If you could imagine for a minute that they are ver they are vaccine researchers, they know that if they can get the cells of the body to, you know, to manufacture this foreign protein, it might be a very effective vaccine. And we know the sequence that we needed to make. So man, if we could only get this messenger RNA into the body in a, in a way that the cells respond, wouldn't that be great.
[00:20:53] So you have a bunch of probably mouse experiments and they've probably tried many different lipid formulations. And so you're a researcher you're trying all these various lipid formulations and you're injecting your mice and you're saying, wow, I'm going to wait two weeks and then I'm going to measure my antibody response to the spike protein.
[00:21:10] See, did they respond? You know, or I'm going to measure the half-life of the, like how long does the messenger RNA to linger in the, in the mouse before it gets totally degraded. So, so you're doing these experiments in one day, you try this particular blend of lipids and wow. It works right. It works better than the other.
[00:21:27] So you're like, you're like Eureka, I have figured this out. Right? And then you send your little liquid preparation down to the electron microscope room and they take images and they see the size of the particles, these lipids, and they're characterizing them. And so on. You know, this, this, this is like what they did.
[00:21:43] They had a Eureka moment, right. Where they were able to suddenly, uh, get this to work. Uh, and not only it's, it's not even, it's partly yes, the formulation. But like I said earlier, even the idea of using messenger RNA was something nobody was doing. They were using, they were doing this with DNA. They were trying to deliver DNA into cells, probably with the same kinds of lipid technologies.
[00:22:08] And so delivering the messenger RNA is, is the, this is the thing that they didn't think would work. And then lo and behold, the. So that's, I think more the true story of what happened. Um, there's a particular, a woman researcher. Um, man, I should've looked her name up before this, but she should be, she should get the Nobel prize for this discovery, lipid vaccine.
[00:22:30] She, she single-handedly pursued this, uh, experimentally believing it would work, showed it would work in her lab and then brought it to another lab that was doing vaccine work right around the time when COVID was breaking out last February or so January, February, and right at the very beginning was starting to work on this.
[00:22:48] And that's why it happened so quickly. It was just perfect timing basically. So we got lucky. We did get very lucky. Can you imagine what would be like now with, uh, we didn't, no one had a vaccine. I mean, we, we would definitely have to just be relying on the masks and someone we haven't talked about yet.
[00:23:03] Is the fact that the virus is no longer the original virus. It's a new version of the virus. In fact, probably many new versions. It's continually making flight changes. I do want to get
[00:23:16] Taylor Ealand: [00:23:16] there, but I'm gonna, I'm going to pause you for a moment, but that's
[00:23:19] Craig Story: [00:23:19] basically they putting us back to the, almost the pre pre vaccine days, almost not quite.
[00:23:25] Taylor Ealand: [00:23:25] So something else that I think would be beneficial for people to understand is the viral biology of how the virus works, right? Because the idea that you get this injection, it goes into your arm and it works is cool. But the virus has many mechanisms that are at play, which make the vaccine preferable, but we have to understand why the virus does what it does before we can explain why the vaccine is preferable, you know, from a mechanism point of view.
[00:23:51] So the virus is my understanding is. It has, we had the spike protein, which everybody knows about. And the spike protein is basically the keys to the kingdom, where it attaches on think of Velcro, I suppose it attaches onto a cell. And thanks to this spike protein on the cell, recognizes it and says, Hey, we can be friends.
[00:24:12] And then the cell membrane, which is also a phospholipid bi-layer, uh, which is similar to those little lipid particles, we were talking about a moment ago, merges with the virus and the virus injects its RNA load into the cell that I get
[00:24:31] Craig Story: [00:24:31] there. Yeah. Yeah. So, so, um, pretty much, uh, yeah, the, I, the idea of the.
[00:24:38] The, the virus having a, a surface protein on its surface that recognize there binds to a normal protein of our, of our cells. That's the key. And so this determines which kind of cells, any particular virus will infect. So the HIV virus affects a particular immune cell because it has its own kind of a spike protein that binds to a protein on those particular immune cells.
[00:25:05] And so the, the receptor of our body that recognizes the coronavirus, spike protein is on the longs. It's actually on lots of different tissues of the body, not just the lung tissue, but, um, it, it, it binds. So the spike protein binds to this receptor. That's doing other things in our body, but it just happens to bind tightly and.
[00:25:28] Then it can become internalized into the cell. So it gets into the cell that's step one of any viruses replication cycle. How, how does it work? Well, it has to get endocytosed or brought into the cell by some means the spike protein in way that's, that's its main job, right? That's that's, that's what it does.
[00:25:47] And so vaccine designers will usually make a vaccine, uh, using that particular viral protein, whatever it is, that's on the cells on the surface of the virus, because. Part of our immune response is to make antibodies against those, those spike proteins and the, the spike protein actually has different shapes that it takes depending on whether it's in the infecting bind, whether it's bound or non bound to the log-in.
[00:26:20] So they actually used structural knowledge of the coronavirus spike protein to design the sequence of amino acids so that it isn't a particular conformation that's more effective at blocking the virus particles. All right, let me rewind the tape on that. You're not only making a spike protein, but you're making this the right spike protein version in terms of its shape its confirmation.
[00:26:43] So that antibodies raised recognizing. VI, sorry that vaccine spike protein will neutralize the virus particles. So your, your immune response happens. You've made antibodies. Then a month later, someone costs on you as COVID. The little viruses are, you know, millions of them are in every droplet of, uh, this person.
[00:27:07] They're, they're, they're heavy spreaders, you know, a nice dinner party. You're talking with them for a little while and they're, they're, they're, you're breathing in all that those little particles start to bind, get into our, um, lung tissue space. And lo and behold, you've got all these anti spike protein antibodies waiting from the vaccine.
[00:27:27] They stick all over the surface of the coronavirus, blocking it from getting into yourself. So that's called virus neutralization. So that's one of the mechanisms that the vaccine, uh, uses to block. Uh, viral infection. So by neutralizing and that's, that's the problem with new variants, which we're going to talk about later is that they avoid some of that.
[00:27:49] Aspects so they can still infect you. But our immune response is able to eradicate them more rapidly due to the other aspects of the immunity that we generate. These decides and buys this other aspects of our immunity. Mainly T-cell immunity that can help get rid of the
[00:28:05] Taylor Ealand: [00:28:05] virus as well. I've heard some people express concerns about the vaccine because they see.
[00:28:11] The spike protein as the end all be all. Um, so they're like, why would I basically make my body a factory of spike proteins when they're going to cause damage anyway? And I just wanted to briefly outline that there's much more to a virus than that. Well, let's
[00:28:26] Craig Story: [00:28:26] talk about that. Let's let's so, so the spike protein itself, uh, is, is merely the, um, the grabby hook that it uses it to get into the cell, but that doesn't actually make you sick.
[00:28:38] Just getting into the cell. A virus particles can get into a cell. It's not going to kill the cell immediately just by the fact that it got into the cell, what actually kills the cell and can cause the damage and the destruction and the inflammation and all the, all the symptoms is the fact that it's churning out thousands and thousands of these particles per cell, and actually very likely to killing the cell in the process of replicating the virus.
[00:29:05] Uh, so, so it's. It's the virus life cycle that in the end license, the seller busts open the cell, releasing Saylor contents, causing inflammation. Um, and so the spike protein is just merely, uh, you know, the, the very beginning of the way the virus gets into the cell, but it in itself is not what is causing, you know, it'd be sick.
[00:29:30] So a single protein being made by a particular cell using biotechnology, using messenger RNA technology. That's not going to make the cell, uh, sick, uh, that is only going to hopefully make protein that gets presented in your immune system to make antibodies, make T cells and give you immunity cellular immunity with memory cells set aside for the future.
[00:29:56] That's what you want. Right.
[00:29:57] Taylor Ealand: [00:29:57] I also do try and play Keno scale with people when I'm talking about it, because if you get immunized with the. Um, RNA vaccines, then the UVA, you're going to get that initial wave of COVID wherever you got it. And you're going to defeat it and it's not going to replicate nearly as much as it would during a natural infection.
[00:30:13] And I often joke, you know, humans are monkeys and monkeys are bad at scale, um, uh, understanding, you know, really big numbers and the difference between the COVID that you would encounter with the vaccine versus the COVID that would grow when you, while also developing natural immunity is incomprehensible as a, as a numbers game.
[00:30:34] Um, it's not an order of magnitude. It's not two orders of magnitude. We're talking multiple, multiple, multiple orders of magnitude, even from a numbers point of view. If the contention that the spike protein is harmful was true, would still be preferable, even though I don't even think that contention.
[00:30:51] Craig Story: [00:30:51] Yes.
[00:30:52] Yes. So the amount of spike proteins being made in an actual infection by virtue of the fact that each cell is producing thousands and thousands of tens of thousands of particles that then infect other cells, which then produce tens of thousands of particles you end up with with, um, numbers of viruses in, in the, in a severely infected person on just the right day, if it peaks and wanes as your infection, uh, reside, reside, uh, sort of resolves itself.
[00:31:18] But yeah, it's, we're talking numbers like 10 to the eighth, you know, huge, huge numbers like per mil or, um, you know, just, this is why this is why when you talk in a little tiny droplets come out that are invisible to your eye, they float around the room. These things are they're full of thousands and thousands of viral particles.
[00:31:38] Uh, and so people do not appreciate. Uh, that concept to that. First of all, the concept that we're always spewing stuff out of our mouth without our, without realizing it. And secondly, the fact that they can float around the room for days and be in and be infective. So the, the, the, the looser fitting masks cut down a lot on the production of those little bits.
[00:32:01] They don't really help filter on the inhale. So if everyone is not wearing masks, that's why that's when that that's simply won't work, because it just takes one person without a mask who doesn't realize that they've been infected. They could have been vaccinated. Now, it doesn't really matter what the Delta, they can still spread it.
[00:32:21] Everyone has to wear a mask in doors to prevent this. Right, but that's, that's the concept people are missing. Uh they're like, I don't want to wear a mask cause I was vaccing. Well, no, the Delta now you can still spread it. I can still spread it. I wear my mask, you know, when I, and when I was shopping here, uh, this is, um, this is mid August and Massachusetts.
[00:32:44] I was shopping at a day hard. Very few people had masks on cashiers and whatnot. Even though this week, CDC is recommending masks worn by everyone in doors for the reasons I just mentioned. Uh, and maybe they changed their, their, uh, view today. But they've been saying this for over a week, at least for a week and a half, two weeks, uh, saying, look, you know, vaccinated, people are gonna spread it.
[00:33:09] Everyone has to wear a mask indoors to block the spread. That's what you gotta do. Poor kids under 12 don't have vaccine and they can also get sick or now. Back to the viral life cycle, which is what we were talking about. The Delta probably has a tighter binding, a more capable spike protein that works better.
[00:33:31] It could also have other biological changes in it and replicate better in the body. So in other words, making more of itself more quickly and getting purchased into the cell more readily. And so along with the ability to spread more effectively, it makes people more sick. So we're starting to see just looking Florida, starting to see emergency rooms, fill up with people in their twenties and thirties.
[00:33:55] Right? Younger people are starting to get sick now when they didn't before. So this is very, very concerning and everyone should be worried about that. Lots of stuff to think about.
[00:34:05] Taylor Ealand: [00:34:05] Right. So I'm going to back up a moment. So we were talking about. The scale of the virus versus the vaccine, just, just for the listener, keep, keep that in mind.
[00:34:13] You know, it, when you don't see it, it's easy to kind of shove it away. And I understand that, but you kind of have to also remember that you also don't see the cells that are being damaged and you would much rather catch this thing. Catch the catcher of ours. Be vaccinated, take it out much more quickly because something else that.
[00:34:38] It needs to be talked about is that the natural immune response takes days, which is the headstart that you get with vaccination. So it's not like you're immediately creating all the tools. You need to fight an infection. Once you get infected, it takes time for the infection to make its ways to immuno a lot that this is where it kicks my butt immunological cells.
[00:34:58] And, you know, we've, we, you can shortcut that process by taking the vaccine. That's important because if you're getting infected, uh, I think Sasha just released a very simple video on this, where it takes. I want to say two days before the, the workers of the immune system even acknowledged a few days, a few days, which a few days of infection, that that can be massive damage, especially if Delta is moving as fast as we think it's moving in the body.
[00:35:27] Like if it's true, that it is replicating faster, that is causing cell damage faster. That is binding more quickly. Two days is a long time.
[00:35:34] Craig Story: [00:35:34] Well, a lot of people can, uh, can get it. Now, the one thing I don't want to forget to mention, and that has to do with how vaccines work in a common misconception, but another thought just occurred to me in that is this, um, are not value that people bandied about in the, in the field.
[00:35:48] And all that is, is like how many people tend to catch the virus from an individual who's infected. So if it's, if it's less than one, then the virus will diminish and disappear. If it's greater than one. Then it will increase in the population. And so for different populations, like say a prison or a hospital or a school, these are not values could vary, right.
[00:36:13] Because of the different behaviors. And if people are wearing masks, that's going to affect it and things like that. So I think the are not of the original virus was around one and a half to two or something like that. Whereas the Delta is between six and seven they're estimating, which is a significant, well, I know, I don't know.
[00:36:32] And you're like, why isn't this? Something that everybody knows this is important for your life people to know these things. So these are of course estimates, but they're, they're estimates based on data and based on epidemiology. Yeah. So that's very, very concerning. I wanted to mention a common misconception people say, oh, Look, I got the vaccine and now I'm catching COVID.
[00:36:52] Well, remember this is a new COVID. It's not the same COVID that you, um, may have worried about last year, a year ago. It's the Delta version. It's it's it's derived from the original COVID. Okay. That aside the misconception is that, oh, somehow the vaccine didn't work because I got infected. Hmm. That's a misconception because vaccines never prevent an infection.
[00:37:17] No vaccine ever prevents an infection. Think about that. So you got your polio vaccine right back in the fifties. Everyone ran out to get the polio vaccine. What a horrible disease there. You got neurological damage. You know, it might've been an iron lung for awhile and hopefully you can get out there still one guy.
[00:37:33] I think he's still alive. He's an iron long since the 1950s, because he's diaphragm is paralyzed. Couldn't, can't breathe without assistance. So. Everyone ran out to get that vaccine. And I mean, a live vaccine for crying out loud. I mean, you mentioned people today, they would freak out. They would never take that thing.
[00:37:50] You know, live, you're going to give me a live virus. Anyway, it was effective. It was, it was, it was an important vaccine. So, but you got the polio vaccine, the fifties, and it was around and the environment. So someone's gonna, you know, in the water, you're gonna, you're gonna maybe get some polio after you've been vaccinated in your, in your water.
[00:38:07] And just, it goes in and starts to infect your intestinal cells and you get a little mini infection and no one ever knows that you got that infection. Cause you fight it off very quickly. Right? That's how vaccines work. They do not prevent an infection. They do prevent you from getting sick or dying. So the good news is that the existing kroner vaccine, um, vaccines as smaller, more than one, they, the vast, vast majority of 99% of the people in the hospitals now are the unvaccinated people that are getting sick.
[00:38:37] We're a really sick, hospital's sick. We're at. People with the vaccine are still losing a sense of smell. In some cases they're feeling really lousy, like the worst flu I've had, but they're not dying and they're not having to go to the hospital. Right. So the vaccine works. Right. But the other hand on the other hand, uh, there's the scary part is that those people, uh, that are vaccinated and getting an infection.
[00:39:00] Yes. They're protected, but they still can spread it to their loved ones and their, and their grandkids and so on and so on. That's, that's the really scary part
[00:39:07] Taylor Ealand: [00:39:07] about it. I want to take a moment and this will not mean as much to you, but it'll mean more to the listener who listened to the URI Dagan episode.
[00:39:13] Urea and I had a quick tip about the vaccines. Vaccines don't stop infection. Yeah. He disagree with that. The semantic difference that we were talking about. Dr. Story just laid out there. There's a difference between an infection and getting sick. So I was looking at it from it. It doesn't stop you from encountering, um, or dealing with the virus when you encounter it.
[00:39:32] And Yuri was saying more along the lines of it's. It stops you from. Getting sick, which yeah. Yeah. It's different. So if you're wondering where that semantic difference came from in that last episode, that's what it was. And I just, I just slipped it under the rug because it was an answer really point that I knew I could deal with later.
[00:39:50] Craig Story: [00:39:50] This is a really, I think this is a really important point because so subclinical infection and infection cycle, that's a technical biology term, meaning that the virus is replicating. That's all it means. Right. You can have an infection and not even know that you've had an infection. In fact, you probably do all the time for many other cold viruses and so on.
[00:40:10] Um, but yeah, um, virulence, or the degree to which he gets sick is, is, is the thing we are trying to avoid. And, and, uh, uh, what's the word, trying to temper that down by being vaccinated, trying to minimize the effects of the sickness, uh, aspect of the infect.
[00:40:30] Taylor Ealand: [00:40:30] Right. So for the listener colloquially, you may see infection and sick as the same thing.
[00:40:35] They're not necessarily the same thing, but they are part of the same process for lack of a better term. I guess we need to talk about variance, but I want to preface this conversation with why I am talking about it and why, why I'm even making this series of episodes. There's a particular professor and he's not the only one doing this, but he is certainly, he's not even, he's an ex professor, but he is the most prominent in.
[00:40:58] I'm going to call it anti-vax field. Because at that point, I think that's where he's done, uh, spreading these ideas that don't get vaccinated. It creates evolutionary pressure. More of our hands will come out. The X-Wing will be useless. It's all used. It's all fruitless. And that's how I met URI Dagon who was on the last COVID episode.
[00:41:15] And basically what's going on that, there's a number of people who normally operate in this sort of internet intellectual space. They make podcasts. And then now they're making lots of content because they look at some bogus papers, uh, which have either been retracted or being refuted over and over and over again about things like IVR Metron about things like breakthrough cases.
[00:41:43] And, you know, they, they bring on people like Dr. Malone, who has there. There's all kinds of confusion because people think science, if it's in a paper, it must be. And that, that I know this is going to break some worldviews. That's not true. If it's in a paper in theory, it's been reviewed and it may be true and it needs to be validated, but scientists are people too.
[00:42:10] They're not infallible to the common flaws of humanity. They lie. They, they fake data. They start with the answer and try and find the ways to get there. And now there are people who say, well, this PhD says I shouldn't get vaccinated because you can pick, you pick a misconception. It makes me infertile.
[00:42:31] That's been busted.
[00:42:33] Craig Story: [00:42:33] Not all papers are equally weighty. Not all papers are of equal value because you know, they may be published in a journal, which is kind of, um, It doesn't have as strict of a peer review process, or maybe, maybe this result is sort of preliminary. And like you said, they were, they were kind of just looking for some kind of correlation and it's a correlation that hasn't really shown a causation.
[00:42:56] And whereas other papers, they set out ahead of time with a particular question that they want to answer. And they prospectively designed study to end at a certain point, not waiting until the data fluctuates until it makes the point they're trying to make so. There are better papers and there their worst papers.
[00:43:15] So, uh, and science progresses it once. But once data is in that's solid data with good controls, that was a well done study, most of them, but most of the time, those kinds of papers, those kinds of results don't really change. People. Think science changes all the time. Well, not if it's a really well done study that that made a very clear, had a really clear result, right.
[00:43:40] That, that is, that is huge. You know, most of the time that doesn't change, it's kind of a weaker studies that often get on the news actually, that. Dead change, you know, then people get like, wow, what should I eat this week? Should I eat fat? Or shouldn't I eat fat should eat carbs tonight carved. Well, a lot of those kinds of studies are just not the best studies.
[00:44:00] And so look at, look at really big studies, but lots of people and look at who is quoting the studies, people that are in the field leaders in the field. Those are the people that, that won't give the, the, the oxygen of, um, of news to these kind of fringe studies. I, I, from Nekton or something like that. I mean, ivermectin as an anti-war medicine, I'm actually friends with one of the guys who worked at the company who developed ivermectin.
[00:44:30] I mean, wouldn't it be great if some other drug, for some other thing, like worked on COVID it's very unlikely, right? Because biology is so specific, the biology that's going to counteract. This virus is going to have to be something very specific for this virus. So it's very unlikely that other than sort of tempering the immune response, which could help, you know, could possibly help, uh, those kinds of general immune suppressive functions could help, but they might not, they might make it worse, right?
[00:45:01] If you suppress your immunity. So, so it's very complicated. Um, have, uh, you know, the best advice is for people to become scientifically literate. And part of that is recognizing good sources of data, good sources of information and reputable sources that publish in the best journals like the journals, like science nature, not to say that now.
[00:45:23] And then a bad paper, doesn't get published in a good journal due to political reasons. But believe me, everybody's watching this very closely in the field and it's highly unlikely that a specious or, um, otherwise crappy paper will get into one of those top journals.
[00:45:38] Taylor Ealand: [00:45:38] Right. Journals are like restaurants.
[00:45:40] There are good restaurants, there are bad restaurants, but they're all still restaurants.
[00:45:45] Craig Story: [00:45:45] You can get food poisoning, you can get food poisoning at some restaurants, you know? Right. Exactly.
[00:45:49] Taylor Ealand: [00:45:49] And the difference between Applebee's and Ruth's Chris may not be obvious from the outside, but once you know, the inner workings of how they work, there's a clear difference between the two restaurants.
[00:45:58] Journals are the same way. Nature. I know nature is a good one. So if I say a nature paper, I are immediately know, oh, this is great. If I see a paper that is published in a very small journal coming out of Argentina, that's not the bag on the journal, but it's not nature. So I'm going to hold a different sort of deference to it.
[00:46:16] And you can, you know, you can question that methodology, but it's the way that the world works.
[00:46:21] Craig Story: [00:46:21] Yeah. And if it's a really very important, fine, like say they found a drug to fight coronavirus, wouldn't just think it would be a nature or science instead of this other journal. I mean, common sense dictates that.
[00:46:35] So more than likely the statistics are just weak, the number of subjects is, is poor. Something's wrong with this study? It's just not, it's not going to hold up. So
[00:46:45] Taylor Ealand: [00:46:45] I, I think URI and I tackled ivermectin pretty well, but I do. So highlight to the listener, the variants that can be created because a lot of people are saying, well, I shouldn't get vaccinated because if I get vaccinated, I'm creating evolutionary pressure to create vaccine resistant variants, which again, we're running back into this.
[00:47:04] Humans are monkeys and monkeys don't understand scale. Why is that just demonstrably false?
[00:47:09] Craig Story: [00:47:09] Yeah. So I mean, if the virus travels around the world on a bait and without any vaccine, there's still going to be variants and those variants are gonna probably be better at infecting us. Um, that's what, that's, what evolution does it, it builds upon what went before and improves upon it.
[00:47:26] And yes. So the good thing is if we get a variant that escapes this vaccine, they can very easily reformulate the vaccine to, you know, give boosters to affect those. But honestly the honest truth is it may be the case that we end up having echoes of this thing echoing throughout the rest of our lives.
[00:47:46] Like as, as another virus that becomes like a human virus. Hopefully though, if say in the worst case scenario, everyone ends up catching, not necessarily Delta, but you know, whatever the next versions are survey, they won't die. Right. I mean, but yet they will develop new antibodies to the new version that will then affect effectively squats that down.
[00:48:11] So maybe we'll end up having sort of a, a, a truce with this thing. If people would only do, you know, cover their face is when they have, when they're feeling sick and, and things like this. We could actually minimize some of the regular disease that we deal with. Like the flu, for example, it's sort of been a revolution.
[00:48:33] And public health knowledge and understanding. I think through this coronavirus experience, I really wish people wouldn't see the mask as this kind of evil enemy thing, but they should see it as a wonderful tool to prevent spread a virus right. And more, and, you know, buy stock in the mass companies.
[00:48:49] Because I think it's a really good tool that I I've never wore a mask when I had a cold ever in my life ever. Right. But why didn't I, I mean, I should have, um, so, uh, yeah, so, so again, the, the vaccines we have will prevent people from dying. You know, this, this that's demonstrably true. Whereas the virus makes people sick and a large number of those people have long-term symptoms.
[00:49:19] And so why wouldn't you want. Um, prevent that. Why would you just right. Think of that as a justification for not getting the vaccine? I mean, in fact, if, if more people had, if we had more vaccine around the world than the Delta wouldn't have appeared at all, most likely, right? So in a way it's, it's a by-product of not enough people being vaccinated.
[00:49:39] Taylor Ealand: [00:49:39] Well, this is the part that I've had trouble getting people to understand is that as we were talking about before, when you get the natural infection, there's a lot more virus and it takes a lot of time. Deal with it. Andrew also expelling more of it because there's just more virus to expel where the same concept does that play with vaccines.
[00:49:56] So they take, they take this idea, which, okay, there's a, there's a credence of truth to it. This idea that a vaccine is going to create evolutionary pressure is in theory, passible, like it passes the sniff test. However, since you're releasing so much less viral load, the chances that any variant that would be created, which probably wouldn't would be created is so many orders of magnitude lower, because there are so many less opportunities for a variant to escape.
[00:50:27] If you're releasing trillions and trillions and trillions of COVID particles, each one of those particles has the potential to be a variant. If you've reduced the number down through vaccination to billions, even it's a huge deal. There's you've already reduced the number of potential. Um, variance by an order of magnitude and that's being ridiculously conservative with the numbers.
[00:50:49] Craig Story: [00:50:49] Yeah. And, and also, uh, you know, if, if people wear masks and, you know, we, we can get that are not number below one, then it will it'll die out. Right. It won't die out. I mean, if you think about it, if we could stop the replication cycle for the next two weeks so that no new infections occurred, boom, it would be gone just around the world would be totally gone.
[00:51:07] Right. That's what they did in some countries like in China and, uh, maybe in Korea and some of these countries, their people listened to authority more, they locked down really quick. And what happened? They had no cases. Right? Sure. It's that simple. So, but people are just not willing to, you know, sacrifice temporarily for a long-term benefit.
[00:51:28] Taylor Ealand: [00:51:28] All right. So we've, we've thrown all kinds of information at the listener, gave him lots of chew on they're going to probably have to real listen to it once or twice to fully get it all. But there's one more thing that I want to talk about. That I keep saying, and it's this excuse, the FDA has not fully approved this vaccine.
[00:51:44] This is an experimental vaccine. And therefore I won't take it. What's that?
[00:51:47] Craig Story: [00:51:47] Yeah. Yeah. I was very curious about that myself and I was, I was a little frustrated with the FDA for like, not fully approving epics. I'm thinking, well, it did the safety enough. Cause he studied, those studies are done. They know it's safe, they know it's effective.
[00:52:01] You know, what, what more are they waiting for? What is it? What is the deal? FDA is like. And so I heard, I heard maybe a few weeks ago, the reasoning behind, uh, this, this lag and this waiting around has to do with things like the label. And the storage conditions for the different vaccines that are there doing like stability studies of how to store it, things like that.
[00:52:26] So, so I think most people assume why wouldn't they, they assume the reason it's in the UAE or the emergency use authorization is because it must maybe they don't know fully that it's fully safe, but I, I believe it has much, much more to do with those kinds of seemingly less important, at least to me, less important things like how to exactly put the label on.
[00:52:47] So why couldn't they maybe, um, in the light of the biology of the pandemic and the urgency. To get more people vaccinated. Why couldn't they have at least put out some statements to educate the public on, well, why is it in the EUA? You know, but I have heard no, no such, you know, official statements, um, by the, by the FDA, I did hear that it's going to be fully, fully approved very shortly.
[00:53:12] Um, maybe in just a couple of weeks, maybe around September, so that's good. I mean, uh, and then those people be like, oh, I guess the safe now. Uh, no, no, we've known a whole while it's safe. It's just a matter of, uh, maybe the labeling will be complete. And, um, I mean, if, if the reason they're not able to fully authorize it with an asterisk is so that they don't have to like redo the labeling information.
[00:53:36] That seems kind of dumb because you know, lives are at stake here. So I wish they had been more forthcoming on that information, but you're right. That is a very confusing thing for people. Yeah.
[00:53:46] Taylor Ealand: [00:53:46] And there's all kinds of legal stuff going on in the background too. Bureaucrats are very, very cautious, which maybe I'll bring on an administrative law attorney and explain that someday.
[00:53:56] But right now the biology is more important. So Dr. Story, thank you for joining me. I appreciate you being so generous with your time. And of course, for the listener, if there's anything you feel that you want clarified, you know how to reach me, send me a message and I'll see if I can find better answers for you, but I want to be respectful of your time.
[00:54:16] So I'm going to go ahead and move on to the next segment of the show. Thank you so much.
[00:54:21] Craig Story: [00:54:21] It was a pleasure. I enjoyed sharing with you guys.
[00:54:25] Taylor Ealand: [00:54:25] Alrighty. Well, that was, it was interesting. Wasn't it? And I'm going to go through a lot of the same things. Um, I have some notes which are going to be in the description of wherever you're listening, hopefully where you can go and check my sources and see the notes that I had prepared prior to this meeting.
[00:54:45] Dr story. And before, you know, get too far into this, I'm going to list sources with the state immense and what you're able to do. It's click on those sources and check my work. Now there's going to be certain people in comment sections that may try and match my one source to my one source. What I would suggest that you look at is the differences in the articles.
[00:55:08] I'm not presenting articles that are providing one finding most of the time. I'm presenting review articles. These review articles have dozens of sources that it within them each, and that's important. So keep in mind that each one of these articles is backed up by many, many more, and I'm not arguing the contentions of any one article, like many people are with say the Carvello study, which was brought up in the URI episode.
[00:55:32] This is an overview of how viruses work, how COVID works, how a vaccine works and treat it as an overview and understand that the overview comes from like a big review article or there's lots of other articles supporting it. It's taking all of the consensus from other articles and making a spark notes of the industry.
[00:55:52] So to speak, to oversimplify it also keep in mind that again, a lot of the same information, but I'm just going to use, you know, other language that maybe more concise or more, um, or my flow better than perhaps the interview did. And also repetition is key, right? For those of you who are trying to learn how the vaccine works, how COVID works and what you should be doing.
[00:56:14] Just consider it like review session. So we know that there are a number of different ways that COVID can harm the body. Uh, for instance, the virus can injure the lungs in three ways. You could have acute respiratory distress in DMS. Um, you could have a alveolar damage, which is basically the sacks that help you breathe when you could have, I'm not going to explain every single one of these, but you can go in the source diffuse thrombo thrombolytic alveolar, microvascular, occlusion, and inflammatory Amenia associated airway inflammation.
[00:56:46] In other words, you can get some swelling in the lungs within the lungs and thrombotic suggests, you know, blood clots. So you can get a class that way. So there's more to COVID than just death. As I said before, and, you know, you could have, um, impaired oxygenation, so oxygen might not be going to the blood as you need it to, uh, which could, you know, cause all kinds of other issues.
[00:57:06] And this is a risk of COVID. This is the, this is a risk that could happen without death. And that's important to understand. There have been cases where there wasn't effective treatment. The consequences of poor oxygenation was either death or permanent lung injury. And that's something you want to be aware of as you're making the decision.
[00:57:24] You know, do I want to naturally back, do I want to get the natural infection, which the answer should be no, in my opinion, I'm going, I'm going to stop. I guess I'm going to editorialize more in a section than I did in the interview. Um, or should I get vaccinated? Which should the degree of cell damage may depend not only on the effects of viral replication, but also on the release of pro-inflammatory cytokines.
[00:57:45] So you may remember in the beginning of the pandemic, something about a cytokine storm. So when you, when you. Cells blow up in the way that Dr. Story and I overviewed earlier, your body has to react. And one of the ways it does it in the beginning stages is this massive release of molecules meant to just destroy everything.
[00:58:07] And that's what it does. It destroys everything. It destroys viruses, it destroys lung tissue. I lost my spot. The cytokine storm can, you know, follow the cell death. It could lead to apoptosis. It could create, um, highly membranes and basically create that alveolar damage that we were talking about before.
[00:58:27] And sorry, I'm trying to decode scientific speak into. Everyday speak in real time. And it's a little harder some article they did this and some it didn't. So basically what can happen is that with the cytokine storm, the cytokine storm can damage your cellular, your cellular mechanisms. They can damage your lung tissue, which is already fragile.
[00:58:44] It's much like the brain where it's not going to heal at the same rate as say your skin, when you cut your skin. And this is going to cause an issue with oxygenation with the blood. Um, it's not permanently, at least temporarily, and this could lead to significant injuries down the road. This could potentially lead to all kinds of other issues, say like poorly Ashton and blood, and you don't oxygenate the brain correctly.
[00:59:07] We, we, we can go down this rabbit hole, the list of injuries it's severe, and the stats are out there. The thing is that they vary, um, they're not insignificant like something. I think Dr. Story said something like a third of people are experiencing brain fog who recover from COVID, which that that's brain damage, um, on some level and.
[00:59:30] You know, you may argue well, I'm you, you may argue the point that I argued at the beginning of the pandemic. Uh, I'm 24 years old. It's not going to hurt me. And it turns out there the answer is technical term should have been. It's not going to kill me very well, may hurt you. And that's not because of the spike protein that's because of the widespread damage caused by the immune response because the virus is basically bursting cells open and the body needs to find a way to contain the toxins that are now being released out into the open environment.
[01:00:01] That is the body. So that's important to keep in mind effective alveolar gas exchange by diffusion depends on the normal function of the cells that are within that part of the lungs. And obviously, as we've been cycling about the last couple minutes, SARS COVID to damage the two major functional components of alveolar gas exchange.
[01:00:20] Basically damages the, the barrier in which that gas exchange can happen. And the function of the they're calling it Abule or microcirculation, that's gonna be circulation of blood and oxygen in the system. That's getting kind of technical, but basically it's saying that it's going to disrupt the ability for your blood to intake oxygen, where it needs to intake oxygen.
[01:00:43] It also induces airway inflammation, which to reduce the inch ventilation function of the airway, the common association with Bronco pneumonia, which COVID-19 pneumonia provides direct evidence that SARS COVID two affects airway ventilation function. So not only can your lungs, not oxygen at the same rate, but you're not getting the same amount of air into your lungs.
[01:01:03] So you're, you're getting a double whammy. You're getting less air because your airway is being affected. And the air that is getting in there, isn't being used as efficiently as it normally should be. Healthy conditions. That's a big deal. Again, this could cause all kinds of damage. This could cause all kinds of neurological symptoms.
[01:01:19] This could cause a shortness of breath. This would make it hard to exercise. This could cause a snowball effect. Please understand this is more than just death. And the article is there. It's linked in the, um, in the show notes, you can follow along if you, so please so with, but an increase in the numbers of COVID 19 patients and the appearance of different symptoms and signs, reports of neurological damage have gradually attracted attention.
[01:01:43] It was initially thought the SARS COVID two had great difficulty in passing through the dense blood brain barrier, but this is not the case. It was more than the studies on the cerebral pathology of COVID-19 patients and the use of an advanced 3d microfluid model of the human blood brain barrier identified three important findings.
[01:01:59] First, despite protein binding receptor AEs two was widely expressed in brain microvascular endothelial cells. That means that COVID can attach to brain cells. At least the microvascular into various cells that are probably on those brain cells. Second, the S protein can directly damage the integrity of the blood brain barrier to varying degrees.
[01:02:19] There are the spike protein can induce the inflammatory response in microvascular endothelial cells that change the function of the blood brain barrier. And he's finding support that SARS COVID two can alter the blood brain barrier and enter the brain and support the appearance of neurological symptoms.
[01:02:33] The formation of fatal microthrombi by one o'clock in the brain, and even the appearance, the occurrence of encephalitis associated with COVID-19. So these neurologic associations of COVID-19 support the clinical reports of early neurological changes and support the potential basis for the occurrence of long-term neurological sequelae.
[01:02:53] In addition to cross the blood-brain barrier SARS, COVID two may enter the brain by transom, lactic, chancellor, optic, and olfactory nerve channels and vascular endothelial cells. So it can go through, it can go through neurons. It can go through cells that connect the brain to the eye, and it can go through your smell pathways as well.
[01:03:13] Now, back in 2020, I have a note that this next part was conjecture, but it was educated conjecture, and it looks like it may be true, uh, after the fact. So it says SARS COVID one and infection of endemic from 2003 was reported to cause various types of neurological damage, including the ExxonMobil variant Goulian Barson.
[01:03:36] Ischemic stroke and seizures. These results provide indirect evidence for possible mechanisms of cerebral damage caused by SARS. COVID two. Now we obviously haven't seen these extreme, uh, symptoms. A ton that I'm aware of, perhaps I'm wrong. And someone will tell me if I am, but it still is important to understand the other viruses of the same family also have been shown to have brain altering symptoms, which means the fact that this one has, is not only a surprise, but was actually not only not a surprise.
[01:04:05] It was to be expected and was expected. This paper came out super early on in the pandemic. The olfactory nerve is now considered to be a potential pathway for entry for the SARS. COVID two into the brain. S so I'm gonna, I'm gonna dry a certain cells that maintain the integrity of sense of smell and stem cells and the olfactory epithelium, all highly expressed ACE two and transmembrane series protease two.
[01:04:26] Again, ACE two is the part where the spike protein can latch onto the cell and not all cells have it, but certain cells do. And that's the problem because that's how COVID inter said cells. Do you remember that conversation with Dr. Story? New York degenerative disease is an umbrella concept, including a range of conditions that primarily affect the neurons in the human brain is one of the key factors leading into the decline of quality of life.
[01:04:47] Whether SARS COVID two causes, narrowed, degenerative diseases or accelerates their premature occurrence is still unclear. I think it's more clear now, and it's also difficult to draw conclusions within just a few months. However, the high expression of the ACE two receptor in a wide range of sites in the brain not only provides an initial target for SARS COVID two to cause acute brain damage.
[01:05:06] They may also be the basis for later. Neurodegenerative changes. This possibility is supported by the findings from recent studies that show the presence of functional inhibition of viral and nicotinic, acetylcholine receptor complexes in the pathogenesis of SARS. COVID two, in fact, Let me just to dumb it down.
[01:05:23] SARS COVID two causes problems in brain. The SARS cov two virus has many unique properties that increase mission and pathogenic effects at such an early stage of the pandemic. The potential longterm sequelae of COVID-19 are just beginning to be realized. They've been more realized. Now this review has highlighted the need for more long-term clinical follow-up data on patients who have had COVID 19 over the attention will management longterm sequelae symptoms.
[01:05:46] If I haven't sent that already, which will emerge in patient care settings. And then of course the economic impact has not really been worked out. So now we're going to move on to a different paper and, and this paper has some educated conjecture from 2020 experiences from other coronaviruses, including MERS and SARS.
[01:06:02] COVID one suggest that fibrotic disease as an outcome of COVID-19 is a concern. A study of Merz noted that in 33% of patients with abnormal chest radiographs x-rays of like that, uh, had lung fibrosis. These patients had longer, ICU stays were older and had higher chest radiographic scores, as well as higher peak lactate dehydrogenase levels versus patients without pulmonary fibrosis.
[01:06:25] They had more problems. Now this is partially to be expected, right? We expect the older to have more problems than the older show that got vaccinated. And by and large, it looks like they did. It looks like at this point, most of the hesitant people are of my generation or perhaps the generation right above me, which, which is odd because you would think it'd be the other way around.
[01:06:39] But the last year we are studies from the first, from the 2003 SARS COVID one virus indicated that 27.8 to 62% of patients. In fact, it was ours. COVID one exhibited decreased lung function and increased fibrosis. That looks to be much like the case with SARS. COVID two, uh, there is a table there and basically what it does is outline all the different damage that could happen.
[01:07:02] Um, And you can have all kinds of cellular injuries. You can have a all kinds of injuries that are related to the cytokine storm, like respiratory distress, immune recruitment. And then of course, there's, you know, the, the regular mechanical stuff that's happened by destroying the cells compounded with age issues, uh, it's table one of the notes.
[01:07:23] Uh, let me find the name summary of fiber genetic mechanisms associated with viral infection. Now you will see people mentioned online or in your light, how their infection went and suggest others to see their experience as the experience. And this is not necessarily the case. I have a very brief review article.
[01:07:40] That's outlining the different types of COVID 19 infections. There's COVID in COVID infection. It's when you have COVID infection, but nobody. These are the people who have tested positive on a screening test, but never reported any major symptoms beyond a low grade fever in my lot, my myalgia. So it is probably in the upper respiratory system only if even there there's, COVID RI COVID infection that is resulting in respiratory infection.
[01:08:05] I believe this is also upper, but may also include, yeah, these occur early stages of disease and presents for longer duration only in elderly or immunocompromised people. So you're not really going to feel this one, especially if you're young. But it's causing damage and you just don't know it yet many diseases into there, but some go further there's COVID I, which is a COVID infection resulting in immunological condition.
[01:08:26] This subset consists of relatively young people with strong immune system who have responded to COVID infection in an unusually strong and atypical fashion, much like auto-immune disease, cytokine storm causing massive damage throughout your lower respiratory system and potentially moving on to your neurological system, big deal.
[01:08:42] And each of these, by the way, I'm, I'm pulling out little parts of the article. The article goes into more depth, if you're interesting. So again, follow the site, check my work, read under the quoted part. And I'm sure you'll find more information if you're interested in about maybe how your infection went or how infection could go.
[01:08:57] So I just did COVID I, so there's COVID S which is. No active infection, but COVID has resulted in residual damage. So this is long COVID. These appear between four weeks and three months in the COVID infection, but potentially longer. And depending on the primary, some type and they affect different organs.
[01:09:11] We're talking again, we're talking to lungs, we're talking to the brain. We're talking. It sounds like even your eyes and your nose, that's a big deal. It's not something I would want. Now there was a site there that I have listed just to see like, oh, I want to see where that site goes. I clicked on that site and it turned out it was the episode I started this episode with it was the, was it was this, the article that I started this section of the episode with.
[01:09:34] So not only are all the sources different, but they're talking to each other and backing each other up. That's important. That's very important, which is not something you see with the, the, the bogus papers that are being brought up by the anti-vaxxers. And when I say anti-vaxxers, I mean, the, the influencers and the YouTube personalities that are peddling, this information, even the widespread disagreement is being thrown their way.
[01:09:59] And the consensus disagrees with them. They're still going to bring up papers like the Karbala paper, which there's not a lot of papers following that back and supporting it. And if there's anything you take from this section of papers that I just talked about is that there's more to COVID than death.
[01:10:15] So, yeah, sure. If you're my age and you're healthy, which, which means you're healthier than me. COVID wait, thanks. COVID you have to keep in mind that just because there's like a one in a thousand chance you die, it doesn't mean there's a 1000 chance that you get hurt. The chances are much higher. And that again, upwards of one third, and choose between the vaccination, which was explained in the previous section.
[01:10:35] And I'll, re-explain it a little bit here. You're going to consider that. And the risk though, I think it's like at most one and a half a million chance of anaphylaxis, which you probably already know if you're alerted to vaccines versus one in third chances of brain fog of brain damage. Essentially. I don't understand how the math comes out.
[01:10:54] You being against the vaccine, unless you think, well, it's experimental. No, it's not. We've already kind of talked about that with Dr. Story, uh, or, or any other typical anti-vax claims that frankly, I don't like, I don't expect everyday people to know better because it's like, I'm not an accountant, so I don't know anything about accounting.
[01:11:13] Uh, it's sort of the same thing. That's why I'm trying to explain it to you, but in the same token, yeah. I think, I see a lot of people who are just saying whatever they can say to justify not taking it. And I imagine those people, the people that I'm actually talking about being anti aren't, listening to the show.
[01:11:28] So I'm not talking about new near listener. I assume it makes sense on some level. Now I want to keep talking about COVID, but there's something else I really want to, and it's because I see this all the time. All right. And you've probably heard about it. It's called there's V a E R S there's is a passive reporting system.
[01:11:51] Meaning that reports about adverse events are not automatically correct. Did that require a port, a report to be filed to theirs, theirs, or it can be submitted voluntarily by anyone, including healthcare providers, patients, or family members reports vary in quality and completeness. They often lack details and sometimes can have information that contains errors.
[01:12:15] That's a quote, that's a direct quote. You might be saying, oh, well, where's that quote from there's dot H H s.gov. There's tells you, tells you their database. Ain't that great. It's better than nothing, but I think that great. There's a little line buried in there in the FAQ that healthcare providers are required to report to the following adverse effects after, after COVID 19 bags.
[01:12:45] And there's more to the quote, but I admitted it just because that happened doesn't mean the vaccine caused it. It just means that something happened after maximum. Right? And that's, again, directly from theirs. It turns out people sharing those graphs, the show like basically no adverse effects in vaccines and this giant spike it's because it was a passive system that nobody knew about.
[01:13:05] Or until this year a and B, when you're fully FDA approved, you don't have to report. Which means once they've COVID vaccines, get FDA approved for. You're going to see those reports drop off a cliff because doctors know that what they're doing, isn't helpful. They have to do it, or else they potentially lose their license.
[01:13:25] They're not going to risk their license, but in the same token, they know like this person got a heart attack. Six weeks after they got the COVID vaccine. Uh, also they had a history of hypertension, probably wasn't the COVID vaccine. Yeah. Yeah. So keep in mind that just because various data exists doesn't mean it's accurate at best.
[01:13:46] If the ceiling at best, you'll see people throw around quotes like, oh, only 1% of adverse effects are reported. That's four things that's at best for like flu shot. The, the, the FDA approved stuff. It's the higher than 1% for COVID. Sorry it is. And it's crap. Also, if you questioned me or you're just like, you don't know crap.
[01:14:08] Yes, I do. I actually downloaded the entire year's worth of adverse effects for COVID-19, um, in the raw Excel file before I played with the database thing that you can do on the CDC website. And I started and I went through it. I didn't go through all of it line by line, cause that would have taken me forever, but I did a lot of scanning.
[01:14:28] I actually have a background. Many of you don't know this. I have a background in medical data entry, so I know how to read patient notes. And I know how to tell when something is caused by something it least from the doctor. Thanks. So, and very, very, I'm gonna say virtually none suggested that there were some were kind of like, I don't know, this just happened.
[01:14:49] Then there's injury. Right? But not very many of those. I didn't find very many of those. Most of what I found was something along the lines, they were vaccinated a few days later they had this issue, but they also had a history of whatever. And as you looked at the age groups of these events, it turned out the older, you were, the more likely you were to have an injury, which suggests older people are sick more often.
[01:15:07] And therefore. Have adverse events, but since they were recently vaccinated, when they went to the doctor, the doctor had to report it, which is kind of silly. And of course also with the added, the added scrutiny that the COVID 19 vaccines are getting people are going to see that their loved ones got vaccinated and then went to the doctor for some issue that maybe started not long after, because that's how injuries work or suddenly people were going to the doctor who hadn't gone to the doctor in years.
[01:15:34] And then they see, oh, I had this problem now, even though they may have had it the whole time, or we're going to develop it anyway. And then either them or a family member reports a diverse, and you have to keep in mind that we're seeing as a scale of vaccination we've never seen before. Right. And when I looked, I, I, the number is higher now, but when I looked there was something like 443,000 bears events reported in the database.
[01:15:56] And you have to compare that with at the same time, there were about 400 million administered doses of all three COVID back. So when I ran those numbers, the chances that you had any sort of injury were very slim. If you were to assume that every various report is accurate, which they're not. And when you looked at the various death reportings there at the time was 4,710 for all of the COVID vaccines, which if you were to assume that all 4,710, and those were accurate, which they're not, and you compared it to the number of vaccines that were out at that 0.1 at a time you had about it was in between one in 1,000,002 in a million.
[01:16:38] And that's being exceptionally generous going to that two in a million with the numbers, let's assume it's right. Let's assume this is an, this is a bad vaccine that kills. And it kills two in a million. The death rate Maxine is so exceptionally lower than the death rate for the virus that it still doesn't make sense to not get maximum.
[01:16:57] And if you're going to wanting to roll the dice and you're going to roll for your, my age. So let's say it's, um, 0.1% death rate one in a thousand versus one in 500,000 being the most generous you can be against the vaccine. I don't understand how with that math, you come out on the other side, thinking vaccines.
[01:17:18] The worst of the two options added on the vaccine does not have the long-term complications that COVID has. As we explained again, in that Dr. Story interview. So keep that in mind. There's also, and here's something to be considered. I know a lot of women are concerned about blood. Especially when I'm on birth control, especially with that puts my atrium back in the category.
[01:17:37] It's an a, it's an, it's a valid concern. I looked up the there's deep vein thrombosis numbers. It's 1,584. In other words, you're more likely to quote die and which again, the numbers are bad, but the numbers are still lower and that's important. And the risk there is again, minor, but you can consult with the doctor again.
[01:17:57] We're going back to, do you want to get, do you want to get blood clots from your lungs when you get COVID or do you wanna get blood clots from, do you want to probably not. And if you do, we're talking now one in 2 million, almost a percent chance of getting. Yeah, that's important. So that all this data was as of August 6th.
[01:18:15] So I understand it's been a little bit, not as an August six, we had something like 193,774,000 people with at least one dose of the vaccine and 165 million, 918,000 that were fully Vaxxed. Um, about 13 million, 674,000 word Johnson, Johnson vaccines. And that's how I know the fully Baxton the first versus second dose were different because I know the number of Johnson, Johnson and Statista was helpful for that.
[01:18:45] Yeah, I didn't put the source there, but I combined the various event sources, uh, numbers with the statista.com sources. So there you can check my work. God, this is such a long episode, but it just has to get out there. So now I talked about bears. There's this bad, don't use it. Okay. It's not a useful database.
[01:19:02] Someone's going to get me on semantics. There for the everyday person is not useful. They could point out that there may be some issues, but even then you have to consider the numbers. Humans are monkeys, monkeys, don't understand scale. If you haven't, if you have something with 1500 events in 400 million doses, you're you're, you're going to be okay.
[01:19:20] And those 1500 events, right? Well, if I remember correctly was 1500 thrombosis events, going back to those women who were concerned about birth control and what gluts and the thrombosis with blood clots mainly happened in older people. So it wasn't even women on birth control. Again, you can go through the various database, you can stratify it all out by you're fine.
[01:19:37] Get vaccinated. Don't anybody who uses bears as a reason to not get vaccinated. Doesn't know what they're talking about. There's no, the way around that statement, there's no way to sugarcoat it. There's no way to be nice about it. There's no way to be like cute with my tone. If you use theirs, if you use theirs to justify not getting the vaccine, you do not know what you're talking about.
[01:20:01] You do not understand the math. You didn't look at the actual database and you don't know how to read medical notes. There's no way around it. I don't care if some PhD there's, they're using it wrong. I'm sorry. It's going to come off a little harsh. I understand. But if you see someone using theirs discount, the argument, it's not good.
[01:20:23] It's not good. This is a, this is a matter of knowing methodology. And I don't know, expect everyone to know this. I don't think everybody should know this. I think it's a waste of time that we have to even go through this. The fact that it's not obvious when you look at the graph of infections over the course of the last year and how, when it dropped a drop, right at the time vaccines showed up and now a new variant comes out and now suddenly there's cases again, which was primarily among the, uh, un-vaccinated that it's even still a question as to whether or not they're effective to me.
[01:20:51] It's mine. Mind blowing. And before I get to, and before I get to the mechanism of COVID-19, I'm also seeing that it may not, the CDC says this, but they don't cite it, which is frustrating for me. If I find the paper, I will let you know about it, follow me on Twitter. I will post it. Um, there, the CDC is suggesting that, well, I guess this easy suggesting that even if you have a national infection, you still only get vaccinated, which would go back to the general virology concept that Dr.
[01:21:18] Storey was telling us about. So I will find a paper that backs that up so that you can wave it to your friends if you so need be, because that's what people do now is just wait, scientific papers at each other. And instead of following the scientific consensus, because let's be real, I'm sorry, plumber.
[01:21:31] You probably don't get the full picture. I'm a biology. I have a BS in biology. I don't get the full picture. So. Keep that in mind. Um, I will find a paper somehow, even if it's not COVID related that points that out. And maybe not, maybe that is probably why the CDC is suggesting vaccination. Even if you have natural immunity, that was new information for me today, by the way.
[01:21:56] So I learned something 10 minutes before y'all did well, I guess I have to record this, but you get the point. So the neck aneurysm of COVID-19. I started in this research to answer the question that is derived from whether or not COVID has long-term side effects. My research then started with this particular article, which came out of the journal of Alzheimer's diseases that states a spike protein facilitates entry into a cell.
[01:22:17] Um, eventually that article led me to another article that stated the mechanisms of the spike protein attaching to said cell. And after learning about how the spike protein attaches to the cell and why the spike, and basically this tells us the spike proteins function I asked, well, what happens after the spike protein attaches to said cell.
[01:22:35] Quote, once the virus enters the cell, the viral RNA is released Paul poly protein that are translated from the RNA genome and replication of transcription of the viral RNA genome occur via protein cleavage in assembly of the replicates transcriptase complex viral RNA is replicated and structural proteins are synthesize assembled and package.
[01:22:54] And the host cell after which viral particles are now, I wanted to get to this with Dr. Story, but we just didn't I'm uh, I thought about it. We had moved on from the conversation, so I knew I would talk about it here. So I don't want to get into the specifics of how scription works pro mainly because I'm going to mess it up and then someone's going to catch me on it.
[01:23:15] And then they're going to use it as an excuse, not to listen to me where the concept is still there, even if I'm my I'm muddy on the details because it's been yeah, a couple of years, but viral RNA is viral RNA, M RNA, all the different kinds of. In A's are all part of a larger process, right? And there's a particular order in which they're created, right?
[01:23:39] So the spike protein is only part of the cells and the, and part of the virus. The virus then injects a bunch of DNA that tells the cell to make everything associated with the virus. This includes more spike protein. This includes the, the, the protein show that protects said viral RNA. That's going to be put in all of the other viruses and this includes everything else.
[01:24:00] The virus needs to do his job. The vaccine only makes spike protein, viral RNA, hijacks cells, and it hijacks cells with the ACE two receptor. Right. And basically only thing cell does make virus. Essentially it's an oversimplification, but it works. That doesn't seem to be the case. With the vaccine also with the viral cells, they're attacking anything with an ACE, two receptor with the vaccine.
[01:24:36] They are mostly starting with dendritic cells, which wouldn't even be touched by an infection of COVID-19 until later on in the process. Generally speaking, potentially even days if Hank Green's researchers, correct. So already you've the damage by direct injecting with the RNA vaccines so that they go straight into the appropriate, the appropriate immune system cells cells, as opposed to a natural infection, which is going to start wreaking havoc in your upper respiratory system, potentially moving to your lower respiratory system.
[01:25:13] At that point, finally, the immune system's starting to kick in. So now it's getting into the immune system. Oh, and if you have a really bad case, it's going to start going into your head. Which one do you want? And go back to that. Doctor story interview turns out viruses actually suppressed the immune response.
[01:25:31] So you might not even get the same. Oh, this is so frustrating. I'm sorry. I'm passionate. I apologize. But it's just, it just irks me so much. You might not even get the same immunity that you would've gotten in the vaccine. Nuts. Absolutely. Nutty, the mine that your cells burst when the virus has done, because the end of the virus lifecycle is punching a hole in the cell.
[01:25:54] And not only is the virus going into the immediate environment was so are cell organelles, which are not supposed to be outside the cell. And now you have other issues. Other toxic waste basically for your body to deal with, as opposed to just at worst with the vaccine, a couple spike proteins, and couple is relative.
[01:26:12] I understand that, but compared to a natural infection, it totally, I got both. So this begs the question, what does viral RNA do? That's what I've said. It basically makes all the components of the virus. It hijacks the cell makes it to the cell, makes all the stuff the virus needs in order to recreate itself.
[01:26:26] And at some point, um, and I couldn't find one, I couldn't find an article specifically for COVID, but it's going to be a similar process to the rest of viruses. It basically is going to send some sort of kill signal that isn't going to be obvious with spike proteins, uh, to then cause the cell to. There's there's more information SARS.
[01:26:46] COVID two is an enveloped, uh, which means surrounded positives that have single-stranded RNA virus, that upon infection of a host cell deploys, a translation ready, RNA molecule. And that's going back to that process. I really didn't want to go into because I'll mess something up and then people will attack me for it, which uses the protein synthesis machinery of the host to express a set of viral proteins.
[01:27:04] Crucial for replication. Spike proteins don't have those critters. So for replication things going for them. All right. So then there was a site there that site also, by the way, was from nature.com. nature.com is a good source. Where does that site go? Psychopathic viruses, including SARS. COVID two induced death and injury, a virus infected cells and tissues as part of the virus replicative cycle.
[01:27:26] So I could find a site for that. I just couldn't find the exact mechanism, which we probably wouldn't even care about anyway, but it does do it. We do know it does it. I just don't know how I'm sure someone does on the world. And I ran out of time for research viral infection and replication in airway.
[01:27:40] Epithelial cells could cause high levels of virus linked pyro, ptosis. I hate big bio words, uh, with associated vascular leakage as shown in patients with SARS COVID I wrote is, you know, what I'm trying to say is, hi, I'm interested to start saying popping. Popping is a highly inflammatory form of program cell death that is commonly seen with cytopathic viruses.
[01:28:02] And this is a likely trigger for this stuff. Inflammatory response, which again could cause issues in your lungs could cause lung damage. You don't want this. And then this can also cause uh, they call it one L one beta. I don't have any better way of saying an important side of Keene released during a popping is elevated during SARS cov two infection.
[01:28:24] So presumably without the viral RNA, this is cell death would not occur in the same fashion if at all. And that's what make the vaccines safer than natural infection should be a duh. But there it is there's sites. You can check my work, but that's where I'm at with it. Other notes, I have found SARS cov, two infection and the destruction of lung cells triggers a local Munis.
[01:28:47] So this is there's a site. This is citing the cytokine response, uh, in the, after the cytokine storm, the cytokine storm, then. Creates another local immune response and immunologist. I know I'm going to get some of these details technically wrong, like on a minor detail. Uh, but there feel free to correct me, but keep in mind the purpose of this.
[01:29:06] Um, it recruits macrophages and monocytes that respond to the infection release sidechains and prime adaptive TMBC T and B cell immune responses. And most cases, this process is capable of resolving the infection. It doesn't mean it's not causing damage in the process. However, in some cases, a dysfunctional immune response secures, which can cause severe long and even system systemic pathology sickness.
[01:29:30] Sometimes your immune system has too good. There is such thing as too good immune system. There's also such thing as too good of cell reproduction. It's one cancer. It's a way you can get cancer. So if you have a really strong immune system, that's very morale on the virus that's going to cause damage.
[01:29:47] It's not going to cause damage if you got vaccinated. Okay. So then how does the vaccine work? Oh, did we not talk about this on the, I don't remember. Okay. So the way Dr. Story explained it to me, and I'm hoping I'm remembering all the relevant details was that you had the syringe, right? The syringe goes into your arm.
[01:30:06] It releases a bunch of liquid into your arm, into your muscular tissue. And then it basically seeps into the dendritic cells, the immuno cells that are re that are responsible for expediting the vaccination process. Right. And we were talking about earlier. So it's not as if, um, it's gonna, and it's not causing gene therapy or any of that, that M RNA can't do that.
[01:30:26] Um, it doesn't even go into the nucleus, right. But basically it's creating this fluid that's in this fluid seeps floozy watch, and then you can see me grab my arm, seeps around the dendritic cells and basically makes the cells make antibodies, blah, blah, blah. And before you know it, you have the tools you need to fight infection off better.
[01:30:43] That's great. That's good news, right? That's what it does. Um, now I'll go through the sites, which again, you can find in that document with sites in all in the show notes below M RNA wouldn't survive in its natural state. So we have to modify it somehow. What are we modifying also, by the way, this modification helps control inflammation, which is good.
[01:31:03] You'd rather have controlled inflammation from a shot, then uncontrolled inflammation from natural infection in your lungs. Um, have I made my point clear yet? I hope so. In an effort half-life as well as translatability and safety, uh, a group of researchers tested a variety of naturally occurring modifications to nucleosides and MRI and a vaccine or molecules, sorry, including, okay.
[01:31:27] I'm not going to go into the specific names, but there they're there. Checking the MRA strand, right. Of these variants, they found that the incorporation of a particular thing in place of your Adeen led to a, um, tenfold increase in translation over unmodified MRNs. So what this means is that was the modified MRMA, would the unmodified MRNs, w let's let's make up numbers?
[01:31:50] You know, they put a, they put a hundred in, let's say they put 10, it was like 10 of them actually worked and was making spike protein so that we can create antibodies, which are bad. Um, and she put in, you know, in this case, if you put a hundred in, there would be a hundred making it. Now that's not a perfect thing bite me.
[01:32:05] I know. But the point is, is that you have a whole order of magnitude, more effectiveness with the modifications they made to the MRI, which means it's not the same MRN name that you would have gotten from the virus, which could be a potentially a good thing, too, I guess. Furthermore, the researchers were able to show in the MRNs molecules possessing.
[01:32:23] This modification did not trigger pathogen associated molecular patterns, sensing mechanisms, such as troll like receptors are other genes. Um, this avoids excess inflammation. So the changes they made make it to where you have less swelling, less inflammation. And by the way, a site that is much preferable than the lungs, uh, with much better effectiveness of creating the proteins necessary to elicit antibody production, big deal, much more preferable to the two natural infection.
[01:32:56] Have I said that yet? Have I said the vaccine is much more preferable to the natural induction? I don't think I've said that yet. So since we're avoiding excess inflammation, this could result in undesired vaccine side effects. It has, um, actually sidebar. I heard us on this during the very section. The side effects were sitting with MRI and vaccines.
[01:33:16] Aren't as bad as the side effects you often see from, you know, more old school vaccines, it all the vaccine hesitant anti-vaxxers knew how old school vaccines work. You all would be terrified. Don't research it. Keep getting vaccinated for these reasons, many candidates, including two recently licensed marinade vaccines adopted this modification in their vaccine design.
[01:33:36] And that's talking about Pfizer. And the next section, I basically paraphrased vaccine changes to amino acids to prevent the spike protein sub units from separating. I'm not going to read you the article part because it confused me, but basically the spike protein is made of two separate parts, right?
[01:33:50] And oftentimes when during an infection, the parts break, it's a mechanism, right? It's part of the structure of the protein and protein structure creates function. So they change the part that links them together to make them harder to split and make them better for creating antibodies. That's what you need to understand about that.
[01:34:08] If you need, even to understand it at all, it's there, there's a longer SU site in the show notes. If you're really interested, Oh, I don't want that fan on right now. And they did this to stabilize the S protein again for antibody creation. Now, talking about this with Dr. Story, but I'm going to repeat it here.
[01:34:25] People have been pointing out that, you know, the MRN vaccines haven't been, um, used for decades. And so why does it suddenly work? Now? It turns out we got lucky with the delivery capsule too, to over simplify. So in order to deliver the marinade to cells, we surround them by liquid nanoparticles that prevents damage with the introduction to the cell, because the body is a hostile place.
[01:34:49] If you just put RNA in the body, the body, the grades, it is just think of it like a string of beads and in the body, it would just come apart. It would untie itself. And once it's in the cell, it untied itself really quickly. So we have to read that string of beads as quickly as we can with the protect, the string of beads until the bead readers are able to read them.
[01:35:07] So we are surrounded by.
[01:35:13] And the part is actually important to you that it turns out the regular liquids that they were trying to use decades. It didn't work, apparently they weren't any bitty enough. The advent of it flip nanoparticle and capsulation was a turning point in the development of MRN vaccines, as LMPs were able to efficiently deliver MRMA in vivo when injected intramuscularly, MRNs L and P is, can be internalized and quickly translated by antigen presenting cells at both the injection site and in draining modes, dendritic cells, that's promoting the initiation of adaptive immune responses.
[01:35:44] Think again, this is much preferable to a natural infection. I don't think I've said that yet. Additionally, peace can protect MRNs from degregation by nuclear nucleuses. Think of them as little organelles that. Eat nucleotides to oversimplify it. Um, although the precise composition of the LMP is used by many vaccine developers is proprietary information.
[01:36:05] Thank you, patent world. It is known the LMP has contained a combination of lipids cholesterol phospholipid and PGS that assemble into about a hundred nanometers nanoparticles encapsulating, the MRNs, the vaccine candidates and clinical trials at L NPS are the standard method for being used to introduce MRMA vaccines to participants.
[01:36:25] We got so lucky that this was found at about the time COVID-19 hit the scene. I didn't realize how lucky we got it. That was just chance, which means that there's good news here. I was under the impression that was just because the whole scientific world was on the task and we figured it out. It turns out that wasn't even the case, but, well, that means that, you know, you know, in the next couple of years, because COVID wouldn't have created more, um, strain on the.
[01:36:54] FDA to approve the vaccines. We would have gotten some really good flu vaccines. So this was coming no matter what. That's awesome. And then RNA stuff is so cool. It's going to fix so much. I'm so excited for it. It's like people don't realize how huge MRMA vaccines are going to be for especially viruses compared to the old stuff.
[01:37:15] There was a reason to antivirals. Weren't very good. There's a reason. There's a reason the flu shot isn't as effective as say the COVID shot. This is good news. Is it the same article? So from the same article, well MRN, a vaccine uptake and bio distribution, and the innate immune response to MRA vaccines are critical for the initiation of adapt to the immunity.
[01:37:34] These processes are thoroughly reviewed elsewhere in other articles, which I kind of sort of talked about and are not covered in this article to do a lack of available data. This was created when the COVID 19 Mexicans were much younger. There's a picture in the notes. That's outlining how the vaccine works.
[01:37:49] That's going into the dendritic cells. It's priming the dendritic cells to make the appropriate antibodies, uh, which again is much more preferable to the infection that would be happening in the respiratory system. Because again, the vaccine nation who is much more preferable to natural infection, that is why there is a picture that tells you exactly why that vaccination is preferable.
[01:38:08] Then when compared to natural infection, natural infection attacks, all kinds of cells, vaccination to the MRNs, vaccines to gifts. Many of those steps go straight to the immune system and prevent cellular damage. Vaccination is preferable to the natural infection. It will cause so much less damage. I even put the picture in the document so you can see it for yourself and read it and check my work and tell me if I'm wrong.
[01:38:37] Is this the best episode on COVID you've ever heard on what? So either MRN Olympians are, we produce antigen are taken up by antigen presenting cells, which are called APCs, uh, such as dendritic cells, these ABCs and traffic to the lymph nodes, where they can able to prime CD four and other lymphocytes.
[01:38:56] Basically it's making the immune system do its job. MRN. Apex zenes have become an increasingly attractive platform to fight the ongoing COVID-19 pandemic for a multitude of reasons. First, the need for only a DNA template of the desired antigen to produce a vaccine candidate result an exceedingly fast manufacturing timeline.
[01:39:13] Let me put it this way. You don't need to make all the other stuff you'd normally would need to make with a old-school vaccine, like a cell line, you would need to make viruses. You would need to make, um, cultures in order to put them in vaccines. And this takes a long time, especially if you need 600 million doses were with him or not, you don't need DNA.
[01:39:32] You need the DNA to make the marinade. It's super easy. It's so much easier. We're talking. Oh, man. The difference in difficulty is absurd. My brain can't comprehend it and I kind of get it so cool. Secondly, MRNs vaccines elicited a very potent immune response in both animal studies and human clinical trials.
[01:39:52] As extensively discussed in section three and section four, importantly, these potent immune responses are substantiated by an impressive protection from COVID-19 in phase two and three studies while the FDA has initially stated that SARS COVID two vaccines would require a minimum of 50% efficacy to qualify for approval.
[01:40:09] Both of the current MRMA vaccines for the alpha strain, uh, currently approved for emergency use authorization reported greater than 94% efficacy years. You've probably seen, um, studies recently that suggest lower numbers. The numbers are lower. They're not nearly as bad as some people may come out to be.
[01:40:26] Even if they are, you will not reduce the damage by 50%, I would still do it because why. Vaccination is preferable to a natural infection, but. I will say there is evidence and, uh, it's on my Twitter page for sure, somewhere. Um, and if I remember, I need to go pull it up and put it in this document. The, the breakthrough cases are still exceptionally rare.
[01:40:55] The vaccinated people are not getting sick as much, and they're certainly not being hospitalized as much as unvaccinated M RNA vaccines also possess additional desirable features compared to other vaccine platforms. And the vaccines are appealing because of their minimalist nature. Yeah. All of those of you who are afraid of vaccines because of all the crap in them, there's less than MRO vaccines.
[01:41:14] Uh, MRNs vaccines do not need a vector dead cell for their delivery expression, thus removing the possible complication. The pre I said, that's all I should say. Dead virus, a possible complication of pre-existing and or Denovo anti vector immunity. In other words, what if you reject the vector because you were already immune to the vector and thus the vaccine efficacy was altered.
[01:41:36] No, that's bad. You don't have that with the LMPs so cool. Uh, differently from inactivated or attenuated vaccines, less important, and genetic targets that do not lead to nib generation are not included since there is no need for the involvement of any viral growth. The possibility of other contaminating viruses from the cell lines is removed.
[01:41:55] You only get the vaccine, no extra guests, no stowaway guests in the airplane, cabin and marinade vaccines that are encapsulated in NLP. LMPs also do not require complex delivery methods, including electroporation as required by DNA vaccines, which we're not using. Um, nor do they need an Agilent, which is required with protein vaccines.
[01:42:15] Now, granted they do need to be cold, but that's a problem that the developed world has solved very easily. Moreover, as described earlier, all available data suggest that MRN a LNP platform polarize the T-cells towards an th one bias suggesting that the likelihood of these vaccines causing adverse events, such as.
[01:42:34] Oh, they call it varied. Um, discussed in another section of the paper is quite well. They say seems quite remote is quite remote, is quite remote because remember, as I said earlier, the various data's garbage. The likelihood that you have an adverse event and marinade vaccines is exceptionally tiny. Any of you have any concerns, talk to your doctor.
[01:42:56] Also when you get the shot, you're supposed to sit there for 15 minutes after you get the shot. In case you do have an immune response, an allergic reaction to which medical personnel, the ones who just jabbed, you are able to treat you and stabilize you. So even if in the very rare, very insurmountably, tiny percent chance that you have of getting hurt by the vaccine, it's probably going to happen within those 15 minutes.
[01:43:23] And you're going to be stabilized there, which you know is much better than catching COVID and dying at home or dying in hospital. Resources are strained. Sorry. That was a little hyperbolic, but you get the point. All right. Finally, MRN, a Maxine's can be readily modified based on need. This is quite possibly the coolest part of this whole development target immunogenic epitopes epitopes can be easily switched in and out of candidates and all that as needed as the DNA sequence of the antigen to serve as a template.
[01:43:52] And I bolded this a SARS COVID two vaccine construct can quickly be adjusted to a target, a newly emerged Corona virus, strain all these people mad about booster shots or the fact that you might need additional vaccines. I'm sorry. This is the new paradigm of flu shot. It's much more effective as far as I can tell.
[01:44:10] As far as I can see from the literature, it's better in basically every way. Welcome to a new normal. And it's a better normal now I get it. Okay. Many of you are against the vaccine for political reasons. And as I said in the beginning of the show, um, separate the politics and science for a moment, right?
[01:44:30] Notice I didn't talk about masks with Dr. Story like me. I sort of let that conversation go, uh, because of policy reasons, you know, I want to talk science and I wanted to talk science of vaccines and I wanted to talk science of COVID-19 right. Keep in mind. That many people are making government arguments for not getting the vaccine and they're coding it in science and this is bad.
[01:44:54] And hopefully I end the recording the beginning after this, hopefully I say all this in the beginning too. You need to, you cannot be free if you're operating with that information. If you've gone this far, and you've only been operating with information given to you by the likes of Bret Weinstein, uh, I'm sorry, I'm glad you're here now and keep them on you.
[01:45:11] You have to keep in mind that the risk in the benefit of the vaccines it's so much skew is skewed so much towards benefit that it doesn't make any sense not to do it. And if, if everyone just did it, we wouldn't have to have the politics conversation if you're scared of the ramifications. And so this is the political part of contracts coming up.
[01:45:32] If you're, if you're conservative like me, in case you have forgotten or didn't know, because this is your first episode, this is a conservative podcast. I am a conservative, I am weary of. Okay. If you are worried about the potential snowball effects of a COVID-19 vaccine mandate or a mask mandate, if you're worried about grams of power, best thing you can do is alleviate the need for the power grab and get vaccinated, please.
[01:45:58] As the best thing you can do to combat the government from taking more power, right, are I don't want to get into policy arguments. I don't want to talk about how policy can only be ticketed designed by can only, it cannot only be dictated by science. Because there's more to life than science. And I don't want to explain that scientists.
[01:46:20] I would rather explain to you the science so that you know, that it is without a doubt, preferable to get vaccinated to where we don't even need to have the discussion. Please get vaccinated. If you're worried about, you know, if you're a minority, for example, and you're worried about things like the experiments that happened on African-Americans in the past, understand that many, many, many of the people I think most of the people might even be that are vaccinated.
[01:46:43] Uh, if you look at the sub categories of groups of races, uh, whites got vaccinated. So if, if this was a grand conspiracy to bring down minorities, it, it failed miserably. Um, please get vaccinated that the science is in your favor. If you don't trust the government, I understand. I don't trust the government either.
[01:47:01] I get it. I get the policy confusion. I get the policy weariness. I get it. I really do as not the conversation. I really want that. If you don't like the idea of a vaccine mandate or passport cards, that's fine. Back in the day when people didn't like the draft, they burned the card. You're going to lose the opportunity to go to certain places.
[01:47:23] That's what protest looks like. If you don't like it, then the pro you're not cut out for the protest. The vaccine is safe. It's remarkably safe for vaccine. It's remarkably safe. It's remarkably effective. The fact that it's still effective against the Delta variant is also really good news. And even if it wasn't, you quickly create new ones and the FDA needs to figure out a quicker way to fast track the approval process based on the science and safety of the vaccine, um, to prevent this type of misinformation to continue to spread.
[01:47:54] This is not as expensive. You think it is. This is not as bad as negatives. This is great news. The fact that you can take, you can take all of my or ours, um, and throw it in. You know, you can take it with a grain of salt. Keep in mind. This is huge. Okay. I'm not telling you to wear a mask. I don't want to have that discussion.
[01:48:14] I think we could maybe not have the mass discussion. If we all got vaccinated, might even wanna go there right now, please get vaccinated so that we can remove the possibility and the government needing to use his own power. And, and here's why I, I try to avoid the policy and discussion here. It was in 1905 Supreme court case that basically says vaccine mandates, uh, when mandated by local governments, alongside of the fine, that would be the equivalent of $150.
[01:48:41] We'll comply, uh, our, our constitutional, so the New York city vaccine mandate, it could be constitutional as with anything. That's not a given that it is, or it isn't, but the Supreme court has spoken in the past. And when there's precedent, the courts tend to follow it. You know, for those of you who are saying it's unconstitutional, I don't think it is.
[01:49:00] I think you should read the article. I think it's article one powers of Congress. There's some something in there about the general welfare of the populous or something like that. And even if it's, you know, unconstitutional state, government's 10th amendment, they can do it and you can choose to leave. I think it's a little cowardly to do that at this point, but it's not a given that states can't mandate it.
[01:49:21] I think the can maybe I'm wrong, but either way, regardless of the policy, the policy shouldn't even be that much of a consideration because the science is so good. And the science isn't changing, what's changing is bad information. Okay. And if a policy maker, a policy maker, um, flip-flops, that is not the same as the effects of the vaccine.
[01:49:47] There are going to be people in the comments section, we're going to challenge what I said, and they're going to say something is not effective. They're going to make it evident. They didn't listen to the whole episode like you did. I'm not engaging with them. I'm not trying to change their mind. There's always been anti-vax movements.
[01:50:03] There always will be anti-vax movements. They're kind of like flat earthers. You, you can't reason with them, but I can reason with you. If you're still listening, ignore their comments. Ignore what they're saying. I understand I'm kind of doing an appeal to authority, but I tried to back it up with sources that you can go read yourself.
[01:50:20] I'm trying to make this hard for you to dismiss. I'm being honest with you up front right here. Right now, Taylor, England is being honest with you. He wants you to trust his work because he brought the receipts and you can follow them. You can roll the receipts, you can follow the rabbit trail and you, and if you look at both positions, the anti-vax position in my position, and even just compare the number of sources supporting mine contention as compared to the numbers were still on the other side.
[01:50:50] It's not even close. You're going to see anti-vaxxers bring up the same four or five papers over and over and over again. They're going to bring up theirs. They're going to bring up all kinds of other bad information, which is easily dismissed. Do not engage. Do we not retweet them? Do we not like their posts get vaccinated, please.
[01:51:13] And if you have friends hesitant who are listening to anti-vax influencers, and I'm going to call Bret Weinstein, anti-vax at this point, if you have friends listening to these people, please, please, please share this episode with them. Please talk them off the cliff. They don't need the well they're anti-vax friends.
[01:51:33] They got vaccinated. You don't need to tell your anti-vax friends. You got vaccinated. Yeah. What you can do is help people who are genuinely confused in scared so that they can get vaccinated so that we can remove the anxiety. Are some of you who get vaccinated still going to get sick? Yes. Especially if people don't get vaccinated, but the likelihood that you get sick will be reduced by a massive amount.
[01:51:58] And the likelihood that you even get hospitalized or reduced again, by a massive amount, you will reduce the damage done to your lungs. You will reduce the damage done to your brain. You will reduce the damage done to you term. So even if you do get sick, you're still going to be better off vaccinated when you were unvaccinated.
[01:52:18] And there will be a very, very, very low number of unlucky people who going to get the full brunt of it in imagine what they would have gotten. If they weren't vaccinated, maybe those are the people that would have died. So now instead of dead, near, alive, but injured, which is still preferable. Why? Because vaccination is preferable to a natural infection.
[01:52:40] Again, call to action. If you know anybody on the fence who needs convincing, share this episode, I brought on a doctor. I'll bring on more. If I need to, I brought my receipts. I'll keep doing research. If I need to, this is a hill I am standing on. I'm going to scream it because I am a scientist in some capacity.
[01:52:59] Even I went to law school, I studied biology for four years. This is something I'm passionate about. This is something I trust. This is something I know to be true. And at least my name is attached to it. And if I am wrong, you can ruin my reputation now, can't you. Thank you for listening. I hope to see you another day.
[01:53:14] That's.